Emulsification and Dispersion Application Materials
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Surfactant-free Pharmaceutical 1
Surfactant-free Pharmaceutical 2
Surfactant-free Chemical
Carbon Material 1
Carbon Material 2
Carbon Material 3
Surfactant-free Pharmaceutical
Surfactant-free Eye Drop Formulation (D-α-Tocopheryl Acetate)
Tocopherol (Vitamin E) is widely used in various pharmaceuticals due to its
excellent antioxidant and anti-inflammatory effects. However, due to its lipophilic nature,
conventional aqueous formulations require large amounts of surfactants for stability. Yet, issues
such as mucosal irritation, reduced absorption rates, destruction of the mucosal protective layer,
and allergies have been identified.
DEBREX is equipment enabling the development of eye drop formulations
with higher concentrations and greater uniformity without surfactants, addressing these
fundamental issues.
Enables development of various surfactant-free lipophilic/liposoluble
drugs beyond eye drops
Commercial eye drop formulations
Non-uniform dispersion
Microscopic observation results of commercial eye drop
formulations
CytoViva (Enhanced Dark field Microscope)
Nikon Eclipse 50i (Polarizing filter/ Olympus, U-PO)
DEBREX
Uniform dispersion and surfactant-free, Ensuring
formulation stability
DEBREX Non-Surfactant Tocopheryl Acetate Emulsion
CytoViva (Enhanced Dark field Microscope)
Nikon Eclipse 50i (Polarizing filter/ Olympus, U-PO)
Surfactant-free Pharmaceutical
Drug Delivery System (DDS)
Recent research is rapidly advancing to maximize bioavailability through drug nano-sizing,
thereby minimizing side effects and maximizing drug delivery efficiency and efficacy.
The most critical aspect of nanomedicines involves encapsulating active ingredients within
targeted sites using various drug delivery systems (DDS), such as liposomes, which are
extensively studied in precision medicine and anticancer agents.
The core of drug delivery systems lies in the stable production of uniform nanoparticles that
maximize in vivo stability. This technological capability is a key factor determining the
quality and therapeutic efficacy of nanomedicines.
DEBREX enables precise control of ultrasonic energy, allowing the production
of uniform nanoliposomes under 100 nm in size. Compared to conventional methods, it offers
superior particle size distribution, reproducibility, and process continuity.
Results of uniform nanoliposome production and particle size
distribution
Liquid-liquid continuous process enables liposome size
control via ultrasonication pass
Over 80% of particles reside within the 50-80 nm range
Turbiscan analysis
Confirmed to remain highly stable without phase separation
or agglomeration
Surfactant-free Chemical
Surfactant-free TiO2 dispersion
TiO2 powder is a high-performance material used across diverse industries: in cosmetics for UV
protection, in printing and coating industries as a white pigment enhancing weather
resistance/heat resistance/chemical resistance, and in pharmaceuticals as a coating agent.
The key to TiO2 powder dispersion lies not merely in uniform mixing, but in achieving uniform
particle size, preventing agglomeration, and maintaining optical properties. DEBREX enables
nano-level TiO2 dispersion without dispersants through its highly uniform energy transfer
capability.
TEM Analysis
Capable of dispersing particles
up to 2-3 times the initial size
up to 2-3 times the initial size
Stability maintained for 24 months without dispersants
Particle size distribution stability evaluation
Carbon Material
SWCNT (Single Walled Carbon Nanotube)
SWCNT is a next-generation nanomaterial simultaneously possessing outstanding electrical
conductivity, thermal conductivity, and mechanical strength. It is gaining attention in various
advanced industries such as semiconductors and batteries.
However, due to its particle characteristics, it exhibits severe agglomeration and is a
material with a complex and highly challenging dispersion process. Achieving stable dispersion
without pretreatment or chemical processing is difficult.
DEBREX enables SWCNT dispersion through a precise ultrasonic process,
ensuring process stability and enabling production scale-up.
ensuring process stability and enabling production scale-up.
DEBREX
SWCNT 1% + Water 99%
SWCNT 1% + Thickener 1% + Water
98%
Carbon Material
Mxene Dispersion
MXene nanoparticles are a carbon-based 2D material, a novel substance with outstanding
electrical conductivity. Regarding dispersion characteristics, it readily disperses in water but
cannot be dispersed in organic solvents.
DEBREX confirmed stability for 30 days at room temperature without surfactants
when dispersed in ethanol.
Mxene Dispersibility Analysis
| Size(μm) | Before | After |
|---|---|---|
| Mean | 100.3 |
5.2 |
| Mode | 72.1 |
4.9 |
| st.Dev | 75.3 |
1.4 |
Carbon Material
Carbon Black
A multifunctional material composed of fine carbon particles, offering excellent conductivity,
UV blocking, and coloring properties. It is used as a key raw material in various industrial
fields such as electrical/electronics, tires, plastics, inks, and coatings.
Solvent: Both organic solvents and aqueous systems (water-based)
are possible
Confirmed uniform particle size distribution after dispersion
Mxene Dispersibility Analysis
