Ultrasonic Extraction Solution
A high-efficiency, low-damage extraction process
solution
based on focused ultrasonic technology
based on focused ultrasonic technology
The Ultrasonic Extraction Solution is a high-efficiency extraction
technology that promotes the release of active compounds by effectively delivering energy into the
raw material using focused ultrasonic technology.
Benefit 01
Low-Temperature Extraction
Stable extraction while reducing damage to heat-sensitive
components
Benefit 02
Reduced Extraction Time
Shortens process time through efficient energy transfer
within the raw material
Benefit 03
Minimized Loss of Active Compounds
Reduces quality-degradation risk with low-temperature,
short-time conditions
Benefit 04
Lower Solvent Consumption
Cuts solvent usage to reduce costs and environmental burden
The Ultrasonic Extraction Solution is a high-efficiency extraction technology that promotes the release of active compounds by effectively delivering energy into the raw material using focused ultrasonic technology. It enables stable extraction even under low-temperature, short-time conditions, minimizing component degradation. By reducing solvent usage, it secures both process efficiency and environmental sustainability. This solution is based on a focused ultrasonic platform scalable from R&D to mass production and can be applied to a wide range of raw materials and processes.
Stable
extraction even under low-temperature, short-time conditions
Scalable
across materials/processes (R&D → production)
Achieves
both process efficiency and sustainability
Extraction Application Data
We are FUST Lab, a company that changes the world through
technology.
Non-destructive
Organic Solvent-free Extraction
Non-destructive Organelle Extraction
Precision Organelle Extraction
Mitochondria extraction within cells enables mitochondria-based drug
development across the pharmaceutical industry, and since it is related to mitochondria
metabolism-associated diseases (Parkinson’s disease, Alzheimer’s disease), it supports a
wide range of R&D applications.
Conventional Technology
Extraction using a centrifuge and homogenizer
Low efficiency, long processing time
Organelle damage
Non-uniform extraction
DEBREX
Focused ultrasonic-based extraction
Enables extraction of specific
organelles without damage
High efficiency via continuous
processing
Uniform ultrasound ensures consistent
extraction quality
Confirmation of Cell Disruption via Ultrasonic Treatment
Before
After
No cell movement observed
Ultrasonic Power Control
Fragmentation rate can be adjusted by power
control
Mitochondria Extraction Study in Human Hepatocytes (WRL-68)
Purpose and Significance
Validated mitochondria extraction technology from
WRL-68 human liver cells to enable liver disease/metabolism research,
mitochondria-based diagnosis/treatment (transplantation, biomarkers), and
biotech product development
Mitochondria are the core organelles for ATP (cellular
energy) production; extracted mitochondria can be used for treatment/diagnostic
research across various diseases including myocardial infarction, Parkinson’s
disease, and Alzheimer’s disease
Applicable to early diagnosis and therapeutic
development for cancer, metabolic, and liver diseases
Key Technologies for Mitochondria Extraction
Efficient extraction without damaging mitochondrial
structure including mtDNA and membrane potential is critical; liver cells are
especially delicate and prone to high loss during extraction
High extraction efficiency and reproducibility are
essential for commercialization
Mitochondria Extraction Results Using Focused
Ultrasonic Technology
Cell line: WRL-68 (human hepatocytes)
Mitochondrial Structural Integrity Analysis
Confirmed that normal morphology was maintained
without structural damage
Mitotracker staining comparison showed ~99%
preservation of outer membrane morphology
Mitochondrial Membrane Potential Analysis
Verified normal formation and preservation of
the mitochondrial outer membrane
TMRE staining analysis showed stable membrane
potential vs. control group (TMRE: 99%)
Organic Solvent-free Extraction
Organic Solvent-free, High-Content Extraction
Conventional active compound extraction processes rely on ethanol, organic
solvents, and high-temperature heating, which can cause various issues such as skin
irritation due to toxic by-products and denaturation of active ingredients. DEBREX is an
ultrasonic extraction system that enables water-based extraction, allowing stable extraction
of high-content, high-purity active compounds.
Chaga Mushroom Extraction
Antioxidant Activity Extraction Results
Antioxidant active compounds improved by about 4x
vs. conventional methods
Schisandra Extraction
Active Compound Yield in Schisandra
Conventional Extraction
Focused Ultrasonic
Active Compound Yield in Schisandra
Before
After
Schizandrin antioxidant compounds showed about 1.8x
higher extraction efficiency vs. conventional methods
Higher extraction efficiency at a lower
temperature: conventional 80℃ / focused ultrasonic 60℃
Soybean Extraction
Active Compound Yield in Schisandra
Heating
Conventional Ultrasonic
Focused Ultrasonic
Active Compound Yield in Schisandra
Heating
Conventional Ultrasonic
Focused Ultrasonic
Albumin content in extract: achieved over 2x
albumin yield vs. heating and conventional ultrasonic methods
Simple temperature control and process, enabling
selective extraction of albumin
Germinated Oat Extraction
Oat Weight Yield Comparison (%)
Ethanol + Water
Focused Ultrasonic + Water
Comparison of Active Compound Yield in Oats
Ethanol + Water
Focused Ultrasonic + Water
Compared to conventional ethanol maceration,
water-based ultrasonic treatment improved extraction efficiency by 3.7x
Extraction efficiency increased by over 30x in
germinated oats compared to regular oats
Amaranth Extraction
Amaranth Weight Yield Comparison (%)
Ethanol
Focused Ultrasonic + Water
Antioxidant Effect Comparison (mgTE/g sample)
Ethanol
Focused Ultrasonic + Water
Significant reduction in extraction time (96%
saved)
Performance improved by 1.69x
Active Compounds in Natural Samples
HPLC Analysis Results of Active Compounds
Sample 1
Sample 2
Sample 3
Sample 4
| Solvent | Temperature | Time | Result | |
|---|---|---|---|---|
| Conventional | 100% Water | 90°C | 180 min | Significant reduction in
processing time Reduced thermal energy consumption |
| DEBREX | 60°C | 15-60 min |
No high-temperature heating process required,
reducing thermal energy use
Shorter processing time compared to conventional
processes
