Ultrasonic Extraction Solution
High-efficiency, low-damage extraction process solution
based on focused ultrasonic technology
based on focused ultrasonic technology
The ultrasonic extraction solution is a high-efficiency extraction
technology based on focused ultrasonic technology,
effectively delivering energy deep inside raw materials to promote the release of active compounds.
effectively delivering energy deep inside raw materials to promote the release of active compounds.
Where Precision Energy Unlocks Purity
Ultrasonic energy penetrates to invisible depths,
selectively separating unwanted elements and precisely extracting only valuable compounds.
selectively separating unwanted elements and precisely extracting only valuable compounds.
Benefit 01
Low-temperature extraction
Stable extraction while reducing damage to heat-sensitive
compounds
Benefit 02
Reduced extraction time
Shortened process time through efficient internal energy
transfer
Benefit 03
Minimized degradation of active compounds
Reduced quality degradation risk under low-temperature and
short-duration conditions
Benefit 04
Reduced solvent consumption
Lower solvent usage reduces both cost and environmental
burden
The ultrasonic extraction solution is a high-efficiency extraction technology based on focused ultrasonic energy, effectively delivering energy deep inside raw materials to promote the release of active compounds. Stable extraction is possible even under low-temperature and short-duration conditions, minimizing compound damage, while reducing solvent usage to simultaneously achieve process efficiency and environmental sustainability. This solution is based on a scalable focused ultrasonic platform that can be applied to a wide range of raw materials and processes, from laboratory research to mass production.
Stable extraction even under
low-temperature and short-duration conditions
Scalability across raw
materials and processes (R&D → mass production)
Simultaneous achievement of
process efficiency and environmental sustainability
Extraction Applications
A company that changes the world through
technology,
this is FirstLab.
this is FirstLab.
Non-destructive
Organic Solvent-free Extraction
Non-destructive Organelle Extraction
Precision Extraction of Cellular Organelles
Mitochondrial extraction from cells enables the development of
mitochondria-based drugs across various pharmaceutical industries,
and supports a wide range of R&D activities related to mitochondrial metabolic diseases such as Parkinson’s disease and Alzheimer’s disease.
and supports a wide range of R&D activities related to mitochondrial metabolic diseases such as Parkinson’s disease and Alzheimer’s disease.
Conventional Technology
Extraction using centrifuges and homogenizers
Low efficiency, long processing time
Organelle destruction
Non-uniform extraction
DEBREX
Focused ultrasonic-based extraction
Enables extraction of specific
intracellular organelles without damage
High efficiency through continuous
processing
Uniform ultrasonic energy ensures
consistent extraction quality
Verification of cell disruption via ultrasonic treatment
Before
After
No cellular movement observed
Ultrasonic Power Control
Fragmentation rate can be controlled through
power adjustment
Study on Mitochondrial Extraction from Human Liver Cells
(WRL-68)
Objective and Significance
Validation of mitochondrial extraction technology from
WRL-68 human liver cells for liver disease and metabolic research,
mitochondria-based disease diagnosis and therapy (transplantation, biomarkers),
and biotech product development
Mitochondria are the core organelles responsible for
ATP (cellular energy) production, and extracted mitochondria can be utilized in
research for treatment and diagnosis of myocardial infarction, Parkinson’s
disease, Alzheimer’s disease, and other disorders
Applicable to early diagnosis and therapeutic
development for cancer, metabolic, and liver diseases
Key Technologies for Mitochondrial Extraction
Efficient extraction of intact mitochondrial
structures, including mtDNA and membrane potential, is critical; liver cells are
particularly delicate, resulting in high loss rates during extraction
High extraction efficiency and reproducibility are
essential for commercialization
Mitochondrial Extraction Results Using Focused
Ultrasonic Technology
Cell line: WRL-68 (human liver cells)
Mitochondrial Structural Integrity Analysis
Confirmed maintenance of normal structure
without morphological damage
Outer membrane morphology preserved at
approximately 99% based on Mitotracker staining comparison
Mitochondrial Membrane Potential Analysis
Verification of proper formation and
preservation of the mitochondrial outer membrane
TMRE staining analysis shows stable membrane
potential compared to the control group (TMRE: 99%)
Organic Solvent-free Extraction
High-content Extraction Without Organic Solvents
Conventional active compound extraction processes rely on ethanol,
organic solvents, and high-temperature heating methods, which cause various issues such as
skin irritation due to toxic byproducts and degradation of active compounds.
DEBREX is an ultrasonic extraction system capable of water-based extraction, enabling stable recovery of high-content, high-purity active compounds.
DEBREX is an ultrasonic extraction system capable of water-based extraction, enabling stable recovery of high-content, high-purity active compounds.
Chaga Mushroom Extraction
Antioxidant Activity Extraction Results
Antioxidant active compounds improved by
approximately 4× compared to conventional methods
Schisandra Extraction
Yield of Active Compounds in Schisandra
Conventional Extraction
Focused Ultrasonic
Yield of Active Compounds in Schisandra
Before Treatment
After Treatment
Schizandrin antioxidant compound extraction
efficiency increased by approximately 1.8× compared to conventional methods
Higher extraction efficiency achieved even at
lower temperatures: Conventional method 80℃ / Focused ultrasonic 60℃
Soybean Extraction
Yield of Active Compounds in Soybean
Heating
Mixed Ultrasonic
Focused Ultrasonic
Yield of Active Compounds in Soybean
Heating
Mixed Ultrasonic
Focused Ultrasonic
Albumin content in extracts achieved more than 2×
higher yield compared to heating and mixed ultrasonic methods
Simple temperature control and process enable
selective extraction of albumin
Germinated Oat Extraction
Oat Weight Yield Comparison (%)
Ethanol + Water
Focused Ultrasonic + Water
Comparison of Active Compound Yield in Oats
Ethanol + Water
Focused Ultrasonic + Water
3.7× higher extraction efficiency achieved with
water-based ultrasonic processing compared to conventional ethanol
extraction
Extraction efficiency increased more than 30× in
germinated oats compared to regular oats
Amaranth Extraction
Amaranth Weight Yield Comparison (%)
Ethanol
Focused Ultrasonic + Water
Antioxidant Activity Comparison (mgTE/g sample)
Ethanol
Focused Ultrasonic + Water
Extraction time reduced by 96%
Performance improved by 1.69×
Active Compounds in Natural Samples
HPLC Analysis Results of Active Compounds
Sample 1
Sample 2
Sample 3
Sample 4
| Solvent | Temperature | Time | Result | |
|---|---|---|---|---|
| Conventional Method |
100% Water | 90℃ | 180 min (3 hours) |
|
| DEBREX Process |
60℃ | 15–60 min (within 15 min–1 hour) |
High-temperature heating processes are
unnecessary, resulting in thermal energy savings
Processing time can be significantly reduced
compared to conventional processes
